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Effect of Botox® on Cervicogenic Headache "Not Significant"

While some studies have suggested that Botox (onabotulinum toxin A) could improve cervicogenic headache, a new, more rigorous study has found no significant difference between Botox and placebo injections.

Cervicogenic headaches originate in the occipital regions of the neck and are accompanied by limited range of motion. They are diagnosed by reproducing the symptoms with positional maneuvers and relieved with a diagnostic occipital nerve block.

The randomized, placebo-controlled, blinded crossover study included 28 adults with long-standing and treatment-resistant cervicogenic headaches. Patients received injections of Botox or of saline at fixed sites in the neck muscles on the same side as their pain. At least eight weeks later, patients received a second round of injections and were then followed for another eight weeks. At the end, there was no significant reduction seen in moderate-to-severe headache days, neck mobility or quality of life.

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