Flurbiprofen is a nonsteroidal anti-inflammatory drug (NSAID) that is indicated for rheumatoid arthritis and osteoarthritis but has also proven to reduce migraine intensity and frequency.

Flurbiprofen can be taken intermittently to treat a headache attack. One study indicated that the efficacy of flurbiprofen in migraine prevention may be comparable with that reported in studies with propranolol, verapamil and naproxen sodium. As with all NSAIDs, gastro-intestinal side effects, such as nausea, abdominal pain or bleeding ulcers, may occur.