Approximately 80% of women who have migraine stop having migraine attacks from the end of the third month of pregnancy until delivery. This is believed to be due to hormonal stability.

During pregnancy, medication use is discouraged unless absolutely necessary. The safety of any medication in pregnancy cannot be assured. Before using any medication for headache, a physician should always be consulted before using medication, including over-the-counter medicatoins. A non-medicinal treatment program can be effective in pregnancy such as biofeedback.