Stadol (generic name: Butorphanol Tartrate) is a potent analgesic agent. It is used for the relief of moderate to severe pain.

Stadol is available in intramuscular or intravenous form, and most recently, as a metered-dose transnasal spray. The transnasal spray of Stadol is not an abortive or preventive drug, but rather a method of administering a pain-relieving drug for the treatment of migraine that has failed more specific anti-migraine medications.

The recommended dosage for initial administration is one spray in one nostril, with a second spray in one hour if needed. Onset of pain relief occurs within 15 minutes. The greatest pain relief is reached in about two hours but lasts for about 4-5 hours.

The nasal mucosa or lining, because of its extensive blood supply, will enhance the absorption of medicines almost to the degree of intravenous or intramuscular injections.

Stadol nasal spray is a Class IV federally controlled substance. There have been many reports of patients abusing this agent. It should only be prescribed with caution in most patients due to its addictive potential.