The relationship between allergies and headache continues to be controversial. Many patients with migraine headache attribute their reactions to certain foods as being an allergic condition. In most cases this is not correct. The vast majority of foods that play a role in migraine contain vasoactive or neuroactive amino acids such as tyramine, dopamine, phenylethylamine or monosodium glutamate that can trigger a migraine. This is not an allergic reaction.