Any number of triggers can bring on a migraine, including such different factors as drinking alcohol, experiencing a change in the weather, and not getting enough sleep. Now one researcher has determined that these common migraine triggers and a host of others can produce oxidative stress in the brain. Such stress is marked by a build-up of damaging molecules called free radicals and can lead to pain. In a study published recently in Headache, Jonathan Borkum, PhD, of the University of Maine’s Department of Psychology, evaluated 2,000 studies about migraine triggers published between 1990 and 2014 and found that nearly all common migraine triggers are capable of generating oxidative stress. Based on those findings, he stated he believes oxidative stress can be a unifying principle behind the types of triggers countless migraineurs experience.