Posted at 22:34h
All questions are answered by:
Richard Wenzel, PharmD
Diamond Headache Clinic Inpatient Unit
St. Josephýs Hospital, Chicago, IL
in Ask the Pharmacist
Perhaps more than any group of medications, the triptans have contributed to the improved recognition and treatment of migraine and other types of headache. Introduced in the United States in 1993, these drugs have been an important catalyst for research, advanced healthcare professionalsý understanding of migraine, and offered an effective drug option to halt attacks, all of which ultimately benefitted thousands of migraine sufferers.
There are now seven triptans available in the U.S. The triptans appear to act in migraine by binding to selected receptors for serotonin found in the blood vessels (5HT1B) and nerve endings (5HT1D). By binding to these receptors, triptans keep migraines from developing or cause them to end.