Methergine, the brand name for methylergonovine maleate, was originally developed for the treatment of postpartum bleeding and for improvement in the uterine tone. It is related to the ergot amine medications. In addition to its effects on the uterus, Methergine also causes constriction of the smooth muscles in the blood vessels.

Serotonin is a neurotransmitter compound critical to the nervous system. Sufferers of migraine and other headaches probably have altered serotonin processing, which results in blood vessel dilation, inflammation and resultant pain. Many medications that are effective in both preventing and aborting migraine and other vascular...

The term vascular headache refers to a group of headache conditions in which blood vessel dilation or swelling is the major component in the production of pain. The blood vessels in the tissues surrounding the head swell, become distended and inflamed, so that the normal...