People with migraine frequently experience additional health problems, and new research indicates that people with celiac disease, inflammatory bowel disease and gluten sensitivity have higher rates of migraine than people without those health concerns. Celiac disease is a digestive disorder that makes it impossible to tolerate gluten, a protein in wheat and some other grains. If it is eaten, a variety of symptoms may result, including abdominal bloating and pain, diarrhea and weight loss. As its name indicates, inflammatory bowel disease is a condition in which the lining of the intestines is inflamed, and a variety of digestive disturbances occur.

Indomethacin (Indocin®) is an analgesic. It is classified as a nonsteroidal anti-inflammatory drug. These are commonly referred to as NSAIDS. Other NSAIDS are also used as analgesics. Indomethacin can be used as a pain reliever or analgesic. It can also be used as a treatment for arthritis, fever or other conditions where inflammation plays a role in creating the symptoms.

The Food and Drug Administration has approved divalproex sodium (Depakote® and Depakote ER) from Abbott Laboratories as a prophylactic medication for migraine headache. However, divalproex sodium is not a new compound. It has been in use since 1983 for treating epilepsy and is also approved as an alternative treatment to lithium for bipolar disorder. Several clinical trials have demonstrated its effectiveness in migraine prevention.