About half of people with migraine who take ibuprofen (Advil®, Motrin®, etc.) will get relief, according to a systematic review of nine studies with a combined total of 4,373 participants. In the studies, just over one-fourth of those who took 400 mgs., and 20% of those who took a 200-mg. dose, were pain-free in two hours compared to 11% of people who took a placebo. Another 57% of those who took the higher dose had their pain reduced to "no worse than mild." Nausea and other migraine-related symptoms also decreased.

Ibuprofen is an analgesic. It is classified as a nonsteroidal anti-inflammatory drug, commonly referred to as NSAIDS. Other NSAIDS are also used as analgesics. Ibuprofen can be used as a pain reliever or analgesic. It can also be used as a treatment for arthritis, fever...

Diflunisal (the generic name for Dolobid®) is a nonsteroidal anti-inflammatory analgesic.  It is a prostaglandin inhibitor and similar to Alleve® and Motrin®. It works for moderate to severe pain and is not habit forming. As with other medications in this class, it may make stomach...