Imipramine (Tofranil®) is an antidepressant medication. It is classified as a tricyclic antidepressant, which refers to its chemical structure. Imipramine, like other tricyclic antidepressants, has been used as an effective treatment for depression, chronic pain and headache prophylaxis.

Prozac (fluoxetine) is an antidepressant affecting serotonin. It is unlike the older tricyclic types such as Elavil® (amitriptyline). It has not been shown to be effective in reducing migraine frequency. It is the earliest compound approved in the group known as serotonin reuptake inhibitors. Several...